Two auronols from Pseudolarix amabilis

J Nat Prod. 1999 May;62(5):767-9. doi: 10.1021/np980469w.

Abstract

Two new auronols, amaronols A (1) and B (2), were isolated from the bark of Pseudolarix amabilis, along with pseudolaric acid B (3), pseudolaric acid C (4), demethoxydeacetoxy-pseudolaric acid B (5), pseudolaric acid B-beta-D-glucoside (6), pseudolaric acid A-beta-D-glucoside (7), and myricetin (8). The structures of amaronols A and B were established by spectral data interpretation as 2,4,6-trihydroxy-2-[(3',4',5'-trihydroxyphenyl) methyl]-3(2H)-benzofuranone and 2,4,6-trihydroxy-2-[(3', 5'-dihydroxy-4'-methoxyphenyl) methyl]-3(2H)-benzofuranone, respectively. Antimicrobial testing results of the eight compounds indicated that only pseudolaric acid B was active against Candida albicans (MIC, 3.125 microg/mL; MFC, 6.25 microg/mL), while myricetin was marginally active against Trichophyton mentagrophytes (MIC, 50 microg/mL).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification
  • Benzofurans / pharmacology*
  • Candida albicans / drug effects
  • Chromatography, High Pressure Liquid
  • Cycadopsida / chemistry*
  • Drugs, Chinese Herbal / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Phenols / chemistry
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Spectrophotometry, Ultraviolet
  • Trichophyton / drug effects

Substances

  • Antifungal Agents
  • Benzofurans
  • Drugs, Chinese Herbal
  • Phenols
  • amaronol A
  • amaronol B