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Science. 1999 May 21;284(5418):1328-33.

Helicobacter pylori virulence and genetic geography.

Author information

  • 1IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy.

Abstract

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

PMID:
10334982
[PubMed - indexed for MEDLINE]
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