J Neurosci Res. 1976;2(3):193-202.

Effects of catecholamines on behavior.

Abstract

The potential for at least partial reversible transition of aggression- and anxiety-type symptomatology suggested searching for a potential biochemical link between subcellular mechanisms involved in the execution of aggression and anxiety. The effects of norepinephrine combined with dopamine and of epinephrine on these two types of behavior were tested. Responses to foot-shock were used to test aggression, extinction of avoidance response was used to test anxiety-type behavior. The results suggested that one of the possible links between the intracerebral processes responsible for execution of aggression- and anxiety-type behaviors is transmethylation of norepinephrine and/or dopamine to epinephrine.

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