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Mol Biol Evol. 1999 Apr;16(4):467-71.

A new genetic distance with application to constrained variation at microsatellite loci.

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  • 1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. lev@vigg.ru

Abstract

Genetic variation at microsatellite loci is supposed to be constrained within some range in allele size. In this case, the average-square distance (delta mu)2 between two diverged populations moves asymptotically around and underestimates the time since the populations had split. A distance based on the between-locus correlation in the mean repeat scores, DR, is introduced. Numerical simulations show that DR is a linear function of time if the constraints are approximated by a linear centripetal force, which might be due to mutation bias toward a definite range or be caused both by directional mutation bias toward larger allele size and by selection against the greater number of repeats.

PMID:
10331272
[PubMed - indexed for MEDLINE]
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