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Curr Opin Lipidol. 1999 Apr;10(2):143-50.

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.

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  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Centre, Dallas 75235, USA.


A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

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