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Curr Opin Lipidol. 1999 Apr;10(2):113-22.

Novel genes for familial combined hyperlipidemia.

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  • 1Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1679, USA.


Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

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