Trends Endocrinol Metab. 1999 Dec;10(1):9-13.

Mechanisms by which Thiazolidinediones Enhance Insulin Action.

Source

Departments of Pharmacology and Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.

Abstract

Thiazolidinediones (TZDs) are an exciting new class of insulin-sensitizing drugs being used currently for the treatment of non-insulin-dependent diabetes mellitus. The molecular target of these compounds is thought to be the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). PPARgamma is expressed predominantly in adipose tissue, yet a major site of TZD-responsive glucose disposal is skeletal muscle. Potential explanations for this paradox are discussed in this review.

PMID:: 10322388; [PubMed - as supplied by publisher]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Review [Mechanisms of action of thiazolidinediones]. [Diabetes Metab. 2001]
Review [Mechanisms of action of thiazolidinediones].
Girard J. Diabetes Metab. 2001 Apr; 27(2 Pt 2):271-8.
Review [PPARgamma and insulin resistance]. [Ann Endocrinol (Paris). 2002]
Review [PPARgamma and insulin resistance].
Girard J. Ann Endocrinol (Paris). 2002 Apr; 63(2 Pt 2):1S19-22.
Review Troglitazone and related compounds: therapeutic potential beyond diabetes. [Life Sci. 2000]
Review Troglitazone and related compounds: therapeutic potential beyond diabetes.
Fujiwara T, Horikoshi H. Life Sci. 2000 Oct 6; 67(20):2405-16.
Review Experimental approaches to study PPAR gamma agonists as antidiabetic drugs. [Methods Find Exp Clin Pharmaco...]
Review Experimental approaches to study PPAR gamma agonists as antidiabetic drugs.
Vázquez M, Silvestre JS, Prous JR. Methods Find Exp Clin Pharmacol. 2002 Oct; 24(8):515-23.
Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. [Mol Cell Biol. 2009]
Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells.
Chung SS, Kim M, Youn BS, Lee NS, Park JW, Lee IK, Lee YS, Kim JB, Cho YM, Lee HK, et al. Mol Cell Biol. 2009 Jan; 29(1):20-30. Epub 2008 Oct 20.

See reviews... See all...

Cited by 1 PubMed Central article

Review Molecular mechanism of insulin resistance in obesity and type 2 diabetes. [Korean J Intern Med. 2010]
Review Molecular mechanism of insulin resistance in obesity and type 2 diabetes.
Choi K, Kim YB. Korean J Intern Med. 2010 Jun; 25(2):119-29. Epub 2010 Jun 1.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mechanisms by which Thiazolidinediones Enhance Insulin Action.
Mechanisms by which Thiazolidinediones Enhance Insulin Action.
Trends Endocrinol Metab. 1999 Dec ;10(1):9-13.

PubMed
Auditory processing in primate cerebral cortex.
Auditory processing in primate cerebral cortex.
Curr Opin Neurobiol. 1999 Apr ;9(2):164-70.

PubMed
A study on severe food reactions in Sweden--is soy protein an underestimated cau...
A study on severe food reactions in Sweden--is soy protein an underestimated cause of food anaphylaxis?
Allergy. 1999 Mar ;54(3):261-5.

PubMed
Monitoring changes in home health care: a comparison of two national surveys.
Monitoring changes in home health care: a comparison of two national surveys.
J Med Syst. 1999 Feb ;23(1):21-6.

PubMed
Novel mutations in the 1alpha-hydroxylase (P450c1) gene in three families with p...
Novel mutations in the 1alpha-hydroxylase (P450c1) gene in three families with pseudovitamin D-deficiency rickets resulting in loss of functional enzyme activity in blood-derived macrophages.
J Bone Miner Res. 1999 May ;14(5):730-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Mechanisms by which Thiazolidinediones Enhance Insulin Action.

Source

Abstract

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information