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Immunol Today. 1999 May;20(5):220-7.

The dynamics of HTLV-I and the CTL response.

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  • 1Institute for Advanced Study, Olden Lane, Princeton, NJ 08540, USA.


Dominik Wodarz and colleagues describe a mathematical model for the in vivo dynamics of human T-cell leukaemia virus type 1 (HTLV-I) infection and the virus-specific cytotoxic T lymphocyte response. They show that a high rate of viral replication is consistent with the relative sequence invariance of HTLV-I and might be necessary to maintain a persistent infection.

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