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Curr Opin Microbiol. 1999 Apr;2(2):202-7.

Glucose repression in yeast.

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  • 1Departments of Genetics and Development and Microbiology, Columbia University, HHSC 922, Box 136, 701 W. 168th Street, New York, NY 10032, USA.


The Snf1 protein kinase is a central component of the signaling pathway for glucose repression in yeast. Recent studies have addressed the regulation of Snf1 kinase activity and elucidated mechanisms by which Snf1 controls repression and activation of glucose-repressed genes. Important advances include evidence that Snf1 regulates the localization of the Mig1 repressor and that Snf1 functions at multiple points to control Cat8 and Sip4, the activators of gluconeogenic genes.

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