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Curr Opin Immunol. 1999 Apr;11(2):135-42.

Pleiotropic changes controlled by the pre-T-cell receptor.

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  • 1Institut Necker, INSERM U373, Faculté de Médecine Necker - Enfants Malades, 156 Rue de Vaugirard, F75730, Paris Cedex 15, France.


The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the alphabeta lineage.

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