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Curr Opin Immunol. 1999 Apr;11(2):172-9.

B cell memory and the long-lived plasma cell.

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  • 1Duke University Medical Center, Department of Immunology, Durham, NC 27710, USA.


The germinal center reaction is pivotal to the induction of B cell memory. The signals that regulate this complex microenvironment, with their cellular and molecular consequences, underpin long-term protective immunity. Recent studies have identified many key regulators of the germinal center cycle and have revealed an array of cellular outcomes that further define the memory B cell compartment.

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