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Curr Opin Immunol. 1999 Apr;11(2):223-8.

Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses.

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  • 1Laboratoire de Synthèse, Structure et Fonction des Biomolécules, UMR 8525, CNRS-Université Lille II-Institut Pasteur de Lille, 1 rue Calmette, 59021, Lille, France.


Many recent studies have demonstrated the flexibility of epitope recognition by the immune system. This can be explored using a particular type of combinatorial peptide library, termed as 'convergent', consisting essentially of closely related molecular species; from this a fuzzy set can be constructed, which comprises several variants of a peptide that would act in synchrony to represent a model antigen and its recognition by the immune system.

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