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Curr Opin Genet Dev. 1999 Apr;9(2):206-17.

Centromere proteins and chromosome inheritance: a complex affair.

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  • 1Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA. kdobie@aim.salk.edu


Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inheritance with the cell cycle in several organisms. A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species.

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