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Curr Opin Genet Dev. 1999 Apr;9(2):152-7.

Activation by locus control regions?

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  • Department of Cell Biology and Genetics, Medical Genetics Centre, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands. grosveld@ch1.fgg.eur.nl


On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.

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