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Curr Opin Genet Dev. 1999 Apr;9(2):152-7.

Activation by locus control regions?

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  • 1Department of Cell Biology and Genetics, Medical Genetics Centre, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.


On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.

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