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Brain Res. 1999 May 8;827(1-2):229-33.

Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus.

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  • 1Department of Physiology, Trinity College, Dublin 2, Ireland.


The effect of intracerebroventricular injection of neuropeptide Y (NPY) was assessed on LTP in dentate gyrus. We report that NPY attenuated LTP and inhibited KCl-induced glutamate release in synaptosomes prepared from dentate gyrus. Activity of the stress-activated kinase, c-Jun NH2-terminal kinase (JNK) in synaptosomes was increased by incubation with NPY or following intracerebroventricular injection. Activation of JNK might underlie the inhibitory effect of NPY on LTP.

Copyright 1999 Elsevier Science B.V.

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