Biochem Mol Biol Int. 1999 Apr;47(4):563-8.

Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines.

Akiyama K, Akao Y, Yokoyama M, Nakagawa Y, Noguchi T, Yagi K, Nishi Y.

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Pharmaceutical Frontiers Research Laboratories, Japan Tobacco, Inc., Yokohama.

Abstract

To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.

PMID:: 10319407; [PubMed - indexed for MEDLINE]

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Co-amplification and concomitant high levels of expression of a DEAD box gene with MYCN in human neuroblastoma. [Genes Chromosomes Cancer. 1995]
Co-amplification and concomitant high levels of expression of a DEAD box gene with MYCN in human neuroblastoma.
Manohar CF, Salwen HR, Brodeur GM, Cohn SL. Genes Chromosomes Cancer. 1995 Nov; 14(3):196-203.
The DDX1 gene maps within 400 kbp 5' to MYCN and is frequently coamplified in human neuroblastoma. [Genes Chromosomes Cancer. 1996]
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Amler LC, Schürmann J, Schwab M. Genes Chromosomes Cancer. 1996 Feb; 15(2):134-7.
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Squire JA, Thorner PS, Weitzman S, Maggi JD, Dirks P, Doyle J, Hale M, Godbout R. Oncogene. 1995 Apr 6; 10(7):1417-22.
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Review Role of DEAD box 1 in retinoblastoma and neuroblastoma. [Future Oncol. 2007]
Review Role of DEAD box 1 in retinoblastoma and neuroblastoma.
Godbout R, Li L, Liu RZ, Roy K. Future Oncol. 2007 Oct; 3(5):575-87.

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