Clin Dysmorphol. 1999 Apr;8(2):117-21.

Early puberty in Williams syndrome.

Cherniske EM, Sadler LS, Schwartz D, Carpenter TO, Pober BR.

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Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA. elizabeth.cherniske@yale.edu

Abstract

Pubertal development was evaluated in nine males and 16 females with Williams syndrome (WS). Our results indicate that puberty in WS occurred earlier than in published population controls; specifically, 90% of menstruating females reached menarche and 83% of pubertal males showed Tanner III pubic hair development prior to the age of 12 years. The sequence of pubertal development was normal, bone age was always consistent with, or in excess of, chronological age, and there was evidence of central (hypothalamic-pituitary mediated) activation as the cause of early puberty in a subset of subjects.

PMID:: 10319200; [PubMed - indexed for MEDLINE]

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