[Hydrophobic nucleus in the primary structure of bovine prolactin]

Vopr Med Khim. 1976 May-Jun;22(3):360-3.
[Article in Russian]

Abstract

In the primary structure of bovine prolactin a hydrophobic fragment 79-88 of the peptide chain was found, which participated in a maintenance of conformation of the hormone molecule in a solution due to hydrophobic interactions. The fragment contained about 50% of leucine residues, which are currently considered as important in determination of three-dimensional structure and biological functions of protein (6).

Publication types

  • English Abstract

MeSH terms

  • Acetates
  • Amino Acids / analysis
  • Animals
  • Butanols
  • Cattle
  • Chromatography, Paper
  • Hydrolysis
  • Molecular Conformation
  • Peptide Fragments / analysis*
  • Prolactin / analysis*
  • Trypsin
  • Water

Substances

  • Acetates
  • Amino Acids
  • Butanols
  • Peptide Fragments
  • Water
  • Prolactin
  • Trypsin