J Acquir Immune Defic Syndr. 1999 May 1;21(1):65-71.

Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study.

Barbosa HS, Bittencourt AL, Barreto de Araújo I, Pereira Filho CS, Furlan R, Pedrosa C, Lessa G, Harrington W Jr, Galvão Castro B.

Source

Department of Pathology, School of Medicine, Federal University of Bahia, Brazil. hschaer@svn.com.br

Abstract

The state of Bahia in the northeastern coast of Brazil is a region in which HTLV-I infection is endemic. This study investigated the characteristics of 28 HTLV-I-associated lymphomas/leukemias in this region. HTLV-I-infection diagnosis was based on serologic study, Southern blot analysis, and polymerase chain reaction (PCR) in neoplastic tissue. The main clinical differences between these lymphomas and adult T-cell leukemia (ATL) cases from other endemic areas were as follows. The mean age was 47 years; 20% of the cases occurred in young adults; and a predominance was found among male subjects (2:1), blacks, and of those of mixed race (96%). Histologically, 20 cases were T-cell pleomorphic leukemia/lymphoma, 5 were Mycosis fungoides-like cutaneous lymphoma, and 3 were CD30+ large-cell anaplastic lymphoma. Immunohistochemistry demonstrated 4 cases of CD8+ lymphoma. Proviral genomic sequences were demonstrated by PCR in 9 lymph node biopsy specimens and in 3 skin biopsy specimens. Southern blot was performed and was positive in 8 cases.

PMID:: 10235516; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Review Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases. [Leukemia. 1998]
Review Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases.
Fouchard N, Mahe A, Huerre M, Fraitag S, Valensi F, Macintyre E, Sanou F, de The G, Gessain A. Leukemia. 1998 Apr; 12(4):578-85.
Non-HTLV-1-associated primary gastric T-cell lymphomas show cytotoxic activity: clinicopathological, immunohistochemical characteristics and TIA-1 expression in 31 cases. [Histopathology. 2002]
Non-HTLV-1-associated primary gastric T-cell lymphomas show cytotoxic activity: clinicopathological, immunohistochemical characteristics and TIA-1 expression in 31 cases.
Hatano B, Ohshima K, Katoh A, Kanda M, Kawasaki C, Tsuchiya T, Shimazaki K, Haraoka S, Sugihara M, Suzumiya J, et al. Histopathology. 2002 Nov; 41(5):421-36.
Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases. [Acta Oncol. 2009]
Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
Bittencourt AL, Barbosa HS, Vieira MD, Farré L. Acta Oncol. 2009; 48(4):598-604.
T-cell malignancies in Brazil. Clinico-pathological and molecular studies of HTLV-I-positive and -negative cases. [Int J Cancer. 1995]
T-cell malignancies in Brazil. Clinico-pathological and molecular studies of HTLV-I-positive and -negative cases.
Pombo de Oliveira MS, Matutes E, Schulz T, Carvalho SM, Noronha H, Reaves JD, Loureiro P, Machado C, Catovsky D. Int J Cancer. 1995 Mar 16; 60(6):823-7.
Review The cutaneous form of adult T-cell leukemia/lymphoma in a woman from the Ivory Coast. Clinical, immunovirologic studies and a review of the African adult T-cell leukemia/lymphoma cases. [Cancer. 1992]
Review The cutaneous form of adult T-cell leukemia/lymphoma in a woman from the Ivory Coast. Clinical, immunovirologic studies and a review of the African adult T-cell leukemia/lymphoma cases.
Gessain A, Caumes E, Feyeux C, d'Agay MF, Capesius C, Gentilini M, Morel P. Cancer. 1992 Mar 15; 69(6):1362-7.

See reviews... See all...

Cited by 1 PubMed Central article

Analysis of human T-cell lymphotropic virus in CD25+ anaplastic large cell lymphoma in children. [Am J Clin Pathol. 2009]
Analysis of human T-cell lymphotropic virus in CD25+ anaplastic large cell lymphoma in children.
Gualco G, Chioato L, Weiss LM, Harrington WJ Jr, Bacchi CE. Am J Clin Pathol. 2009 Jul; 132(1):28-33.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopatholog...
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study.
J Acquir Immune Defic Syndr. 1999 May 1 ;21(1):65-71.

PubMed
Vitamin D supplementation enhances the beneficial effects of weight loss on card...
Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
Am J Clin Nutr. 2009 May ;89(5):1321-7. Epub 2009 Mar 25 .

pubmed
Food, livestock production, energy, climate change, and health.
Food, livestock production, energy, climate change, and health.
Lancet. 2007 Oct 6 ;370(9594):1253-63.

PubMed
Consumption of cod and weight loss in young overweight and obese adults on an en...
Consumption of cod and weight loss in young overweight and obese adults on an energy reduced diet for 8-weeks.
Nutr Metab Cardiovasc Dis. 2009 Dec ;19(10):690-6. Epub 2009 Apr 8 .

pubmed
Epidemiologic relation between HIV and invasive pneumococcal disease in San Fran...
Epidemiologic relation between HIV and invasive pneumococcal disease in San Francisco County, California.
Ann Intern Med. 2000 Feb 1 ;132(3):182-90.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information