The quality of life (QOL) in patients with cancer in the head and neck regions has become an increasingly important factor in medical treatment. We examined the effect of a prosthesis on the QOL based on the patients' own subjective evaluations. Sixty-eight head and neck cancer patients who had been treated in the Department of Prosthetic Dentistry of the Faculty of Dentistry, Kyushu University, were compared with 35 denture wearers as a control. General denture satisfaction in the control group showed a statistical correlation with eating (P<0.01, t-test; rho = 0.72, Spearman rank correlation), aesthetic satisfaction (P<0.01, rho = 0.57) and pain (P<0.01, rho = 0.51). On the other hand, for cancer patients, general denture satisfaction showed a statistical correlation with not only eating (P<0.01, rho = 0.34), aesthetic satisfaction (P<0.01, rho = 0.33) and pain (P<0.01, rho = 0.41) but also health (P<0.01, rho = 0.33) and mental well-being (P<0.01, rho = 0.41). A statistical correlation between the Denture score and the QOL score was thus observed in cancer patients (P<0.0001, rho = 0.56), while the correlation for the control group was not statistically significant. This study showed that oral prostheses for head and neck cancer patients are important factors not only for eating but also for the overall patient QOL.