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    J Immunol. 1999 May 15;162(10):5917-23.

    Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.

    Source

    Departments ofImmunology and Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada.

    Abstract

    The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function.

    PMID:
    10229828
    [PubMed - indexed for MEDLINE]
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