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Nat Med. 1999 May;5(5):554-9.

NF-kappaB is activated and promotes cell death in focal cerebral ischemia.

Author information

  • 1Department of Neurology, University of Heidelberg, Germany.

Abstract

The transcription factor NF-kappaB is a regulator of cell death or survival. To investigate the role of NF-kappaB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-kappaB was activated, as determined by increased expression of an NF-kappaB-driven reporter transgene, nuclear translocation of NF-kappaB in neurons and enhanced DNA binding of NF-kappaB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-kappaB in focal ischemia. NF-kappaB may provide a new pharmacological target in neurologic disease.

PMID:
10229233
[PubMed - indexed for MEDLINE]
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