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J Immunol. 1999 May 1;162(9):5547-55.

Regulation of inflammatory responses by oncostatin M.

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  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA. philipvwallace@msn.com

Erratum in

  • J Immunol 2000 May 15;164(10):5531.

Abstract

Oncostatin M (OM) is a pleiotropic cytokine produced late in the activation cycle of T cells and macrophages. In vitro it shares properties with related proteins of the IL-6 family of cytokines; however, its in vivo properties and physiological function are as yet ill defined. We show that administration of OM inhibited bacterial LPS-induced production of TNF-alpha and lethality in a dose-dependent manner. Consistent with these findings, OM potently suppressed inflammation and tissue destruction in murine models of rheumatoid arthritis and multiple sclerosis. T cell function and Ab production were not impaired by OM treatment. Taken together these data indicate the activities of this cytokine in vivo are antiinflammatory without concordant immunosuppression.

PMID:
10228036
[PubMed - indexed for MEDLINE]
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