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Neurology. 1999 Apr 22;52(7):1507-10.

Intranasal sumatriptan for the acute treatment of migraine in children.

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  • 1Neuropediatric Department, University Hospital for Children and Adolescents, Erlangen, Germany. Michael.Ueberall@kinder.med.uni-erlangen.de


Sumatriptan is a highly effective treatment for migraine in adults but its efficacy in children has not been determined. Fourteen children with migraine (6.4 to 9.8 years of age; seven girls, six with aura) participated in a randomized double-blind placebo-controlled crossover study to evaluate the efficacy of sumatriptan nasal spray. After sumatriptan, 12 of 14 (versus 6 of 14 after placebo) reported a decrease in pain intensity (p = 0.031); complete headache relief was obtained in 9 of 14 after sumatriptan versus 2 of 14 after placebo (p = 0.016). Migraine-associated symptoms were also significantly reduced by sumatriptan.

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