The pharmacological basis and pathophysiological s...[Fundam Clin Pharmacol. 1999]

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1: Fundam Clin Pharmacol. 1999;13(2):145-53.Links

The pharmacological basis and pathophysiological significance of the heart rate-lowering property of diltiazem.

O'Connor SE, Grosset A, Janiak P.

Department of Cardiovascular Research, Synthélabo Recherche, Chilly-Mazarin, France.

The calcium channel blocker diltiazem lowers heart rate in man and this property probably contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This review examines the pharmacological basis of diltiazem's heart rate-lowering activity and considers its pathophysiological significance. The points discussed include the potent direct inhibitory effect of diltiazem on the sinus node and the frequency-dependence of this action. In addition, the well-balanced tissue selectivity profile of diltiazem and its ability to modulate cardiac reflex responsiveness contribute by counteracting the potential for reflex tachycardia.

PMID: 10226758 [PubMed - indexed for MEDLINE]

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[Circ Res. 1983]
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[Ter Arkh. 2006]
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Acta Pharmacol Toxicol (Copenh). 1985; 57 Suppl 2:31-43.

[Acta Pharmacol Toxicol (Copenh). 1985]
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[Pharmacotherapy. 1996]
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Diltiazem (Cardizem® , Cardizem® CD, Cardizem® LA, ...)
Diltiazem is used to treat high blood pressure and to control chest pain (angina). Diltiazem is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have...
Amlodipine (Norvasc, Vascor, Cardizem, ...)
How do calcium channel blockers compare in treating hypertension?
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