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Anticancer Res. 1999 Jan-Feb;19(1A):365-8.

Biphasic action of vitamin E on the growth of human oral squamous carcinoma cells.

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  • 1Hormone Research Laboratory, University of Missouri-Kansas City, School of Dentistry 64108, USA.


Treatment of human tongue squamous carcinoma cell, SCC-25, with physiological concentrations of vitamin E succinate (VES) which varied from 0.001 to 50 mumoles/L resulted in significant dose-dependent stimulation of cell growth. Whereas, pharmacological doses of the vitamin (100-154 microM) induced significant inhibition in cell growth. The possible anticarcinogenic mechanisms of action of vitamin E are discussed.

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