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1: Curr Opin Chem Biol. 1999 Apr;3(2):152-7.Click here to read Links

Fe-S proteins in sensing and regulatory functions.

Beinert H, Kiley PJ.

Institute for Enzyme Research, Graduate School, Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, 1710 University Avenue, Madison, WI 53705, USA. hbeinert@facstaff.wisc.edu

In the past five to ten years, it has become increasingly apparent that the function of Fe-S clusters is not limited to electron transfer, a function implicit in their discovery. We now know that the vulnerability of these structures to oxidative destruction is used by nature in sensing O2, iron, and possibly also nitric oxide. Changes in the oxidation state of Fe-S clusters can also serve as a reversible switch.

PMID: 10226040 [PubMed - indexed for MEDLINE]