Sensitivity of spermidine-deficient Saccharomyces cerevisiae to paromomycin

Antimicrob Agents Chemother. 1999 May;43(5):1314-6. doi: 10.1128/AAC.43.5.1314.

Abstract

Spermidine-deficient Saccharomyces cerevisiae cells are much more sensitive to paromomycin than nondeficient cells, resulting in cessation of growth and cell death.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Paromomycin / pharmacology*
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Spermidine*

Substances

  • Anti-Bacterial Agents
  • Paromomycin
  • Spermidine