Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biol Chem. 1999 Mar;380(3):293-7.

The role of the proteasome system and the proteasome activator PA28 complex in the cellular immune response.

Author information

  • 1Institut für Biochemie-Charité, Humboldt-Universität zu Berlin, Germany.

Abstract

The generation of antigenic peptides bound and presented to the immune system by MHC class I molecules predominantly depends on the function of the proteasome system. Stimulation of cells with interferon gamma induces the incorporation of three active site bearing beta-subunits into the 20S proteasome and the formation of the PA28 proteasome modulator complex. PA28 alters the cleavage properties of the proteasome and enhances MHC class I antigen presentation. Thus, by cytokine induced change of the proteasome system cells may alter the proteolytic properties of the 20S proteasome and may render an organism more flexible in its peptide generation capacity.

PMID:
10223331
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for iFactory
    Loading ...
    Write to the Help Desk