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Int Clin Psychopharmacol. 1999 Jan;14(1):33-6.

Nocturnal eating/drinking syndrome and neuroleptic-induced restless legs syndrome.

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  • 1Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima City, Japan.


Nocturnal eating/drinking syndrome secondary to neuroleptic-induced restless legs syndrome (RLS) occurred under treatment with low-dose haloperidol in a 51-year-old female schizophrenic patient. Polysomnographic investigation showed a low level of sleep efficacy, periodic leg movements, and a strict relationship between nocturnal eating episodes and non-rapid eye movement sleep. Her nocturnal eating and RLS were completely inhibited by clonazepam treatment. To our knowledge, this is the first published case of nocturnal eating/drinking syndrome secondary to neuroleptic-induced RLS.

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