J Hered. 1976 Nov-Dec;67(6):336-8.

Random determination of a developmental process: reversal of normal visceral asymmetry in the mouse.

Abstract

Situs inversus viscerum in the mouse has been shown to be inherited as an autosomal recessive trait (gene symbol iv) with reduced penetrance. It is hypothesized that the normal allele at the iv locus exhibits complete dominance and controls normal visceral asymmetry. Absence of this control allows the situs of visceral asymmetry to be determined in a random fashion. This hypothesis also appears to apply to the inheritance of situs inversus in man and to the experimental production of situs inversus.

PMID:: 1021593; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Molecular Biology Databases

KOMP Repository

Research Materials

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Reversal of left-right asymmetry: a situs inversus mutation. [Science. 1993]
Reversal of left-right asymmetry: a situs inversus mutation.
Yokoyama T, Copeland NG, Jenkins NA, Montgomery CA, Elder FF, Overbeek PA. Science. 1993 Apr 30; 260(5108):679-82.
Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. [Nature. 1996]
Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.
Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn MR. Nature. 1996 May 9; 381(6578):158-61.
The development of asymmetry: the sidedness of drug-induced limb abnormalities is reversed in situs inversus mice. [Development. 1989]
The development of asymmetry: the sidedness of drug-induced limb abnormalities is reversed in situs inversus mice.
Brown NA, Hoyle CI, McCarthy A, Wolpert L. Development. 1989 Nov; 107(3):637-42.
Review Establishment of left-right asymmetry in vertebrates: genetically distinct steps are involved. [Ciba Found Symp. 1991]
Review Establishment of left-right asymmetry in vertebrates: genetically distinct steps are involved.
Brueckner M, McGrath J, D'Eustachio P, Horwich AL. Ciba Found Symp. 1991; 162:202-12; discussion 212-8.
Review Two rights make a wrong: human left-right malformations. [Hum Mol Genet. 1998]
Review Two rights make a wrong: human left-right malformations.
Casey B. Hum Mol Genet. 1998; 7(10):1565-71.

See reviews... See all...

Cited by 15 PubMed Central articles

Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow. [BMC Dev Biol. 2010]
Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.
Stevens J, Ermakov A, Braganca J, Hilton H, Underhill P, Bhattacharya S, Brown NA, Norris DP. BMC Dev Biol. 2010 May 20; 10:54. Epub 2010 May 20.
Review The evolution and genetics of cerebral asymmetry. [Philos Trans R Soc Lond B Biol...]
Review The evolution and genetics of cerebral asymmetry.
Corballis MC. Philos Trans R Soc Lond B Biol Sci. 2009 Apr 12; 364(1519):867-79.
Review Why are some people left-handed? An evolutionary perspective. [Philos Trans R Soc Lond B Biol...]
Review Why are some people left-handed? An evolutionary perspective.
Llaurens V, Raymond M, Faurie C. Philos Trans R Soc Lond B Biol Sci. 2009 Apr 12; 364(1519):881-94.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Random determination of a developmental process: reversal of normal visceral asy...
Random determination of a developmental process: reversal of normal visceral asymmetry in the mouse.
J Hered. 1976 Nov-Dec ;67(6):336-8.

PubMed
Alterations in the expression of GABAA receptor subunits in cerebellar granule c...
Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene.
Eur J Neurosci. 1999 May ;11(5):1685-97.

PubMed
Identification of a novel human adenylate kinase. cDNA cloning, expression analy...
Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.
Eur J Biochem. 1999 Apr ;261(2):509-17.

PubMed
Lichen sclerosus in adult men: a study of HLA associations and susceptibility to...
Lichen sclerosus in adult men: a study of HLA associations and susceptibility to autoimmune disease.
Br J Dermatol. 1999 Jan ;140(1):79-83.

PubMed
Effect of electrostatic charge in plastic spacers on the lung delivery of HFA-sa...
Effect of electrostatic charge in plastic spacers on the lung delivery of HFA-salbutamol in children.
Br J Clin Pharmacol. 1999 Mar ;47(3):333-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: