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The tobacco mosaic virus particle: structure and assembly.
MRC Laboratory of Molecular Biology, Cambridge, UK.
A short account is given of the physical and chemical studies that have led to an understanding of the structure of the tobacco mosaic virus particle and how it is assembled from its constituent coat protein and RNA. The assembly is a much more complex process than might have been expected from the simplicity of the helical design of the particle. The protein forms an obligatory intermediate (a cylindrical disk composed of two layers of protein units), which recognizes a specific RNA hairpin sequence. This extraordinary mechanism simultaneously fulfils the physical requirement for nucleating the growth of the helical particle and the biological requirement for specific recognition of the viral DNA.
PMID: 10212932 [PubMed - indexed for MEDLINE]
PMCID: PMC1692534
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Cited by 11 PubMed Central articles
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Nanoscale magnetic resonance imaging.
Degen CL, Poggio M, Mamin HJ, Rettner CT, Rugar D.
Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5):1313-7. Epub 2009 Jan 12.
[Proc Natl Acad Sci U S A. 2009]
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A templating approach for monodisperse self-assembled organic nanostructures.
Bull SR, Palmer LC, Fry NJ, Greenfield MA, Messmore BW, Meade TJ, Stupp SI.
J Am Chem Soc. 2008 Mar 5; 130(9):2742-3. Epub 2008 Feb 12.
[J Am Chem Soc. 2008]
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Packaging of a polymer by a viral capsid: the interplay between polymer length and capsid size.
Hu Y, Zandi R, Anavitarte A, Knobler CM, Gelbart WM.
Biophys J. 2008 Feb 15; 94(4):1428-36. Epub 2007 Nov 2.
[Biophys J. 2008]
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