Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 1999 Apr;11(2):203-10.

Costimulatory regulation of T cell function.

Author information

  • 1Howard Hughes Medical Research Institute, Cancer Research Laboratory, Department of Molecular and Cellular Biology, 415 Life Science Addition, University of California, Berkeley, CA 94720, USA. chambers@socrates.berkeley.edu

Abstract

During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.

PMID:
10209159
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk