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    Curr Opin Cell Biol. 1999 Apr;11(2):203-10.

    Costimulatory regulation of T cell function.

    Source

    Howard Hughes Medical Research Institute, Cancer Research Laboratory, Department of Molecular and Cellular Biology, 415 Life Science Addition, University of California, Berkeley, CA 94720, USA. chambers@socrates.berkeley.edu

    Abstract

    During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.

    PMID:
    10209159
    [PubMed - indexed for MEDLINE]

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