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Curr Opin Cell Biol. 1999 Apr;11(2):219-25.

Signalling through phosphoinositide 3-kinases: the lipids take centre stage.

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  • 1Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. sallyl@ludwig.ucl.ac.uk


Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4,5) P3. Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.

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