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Curr Opin Cell Biol. 1999 Apr;11(2):190-6.

Multiple positive and negative regulators of signaling by the EGF-receptor.

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  • 1Howard Hughes Medical Institute, Division of Biology, 156-29 Caltech, 391 South Holliston Avenue, Pasadena, CA 91125, USA.


Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and modulation by multiple ligands, effectors and negative regulators, as well as regulation by heterodimerization between family members and crosstalk between heterologous signaling pathways. Besides serving as a paradigm for receptor tyrosine kinases in general, this family is crucial for development and is often mutated or amplified in human tumors.

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