Curr Opin Cell Biol. 1999 Apr;11(2):184-9.

Epidermal growth factor receptors: critical mediators of multiple receptor pathways.

Hackel PO, Zwick E, Prenzel N, Ullrich A.

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Department of Molecular Biology, Max Planck Institut für Biochemie, AmKlopferspitz 18A, 82152 Martinsried, Germany.

Abstract

Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream element in different signaling pathways. This expanded its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network. In addition, several downstream targets, (e.g. Smad proteins and STATs) into which signals from synergistic and antagonistic signaling pathways converge, were identified.

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