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Curr Opin Cell Biol. 1999 Apr;11(2):177-83.

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

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  • 1The Howard Hughes Medical Institute, Departments of Medicine, Surgery and Biochemistry, Box 3821, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.

PMID:
10209148
[PubMed - indexed for MEDLINE]

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