Warning: The NCBI web site requires JavaScript to function. more...
The Howard Hughes Medical Institute, Departments of Medicine, Surgery and Biochemistry, Box 3821, Duke University Medical Center, Durham, NC 27710, USA.
Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on