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Curr Opin Biotechnol. 1999 Apr;10(2):142-5.

Modifying secretion and post-translational processing in insect cells.

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  • 1Department of Chemical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.


The baculovirus-insect cell system is a valuable tool for the expression of heterologous proteins. Due to limitations in the intracellular processing environment, however, heterologous secreted and membrane proteins are often insoluble, poorly processed, or contain 'non-human' modifications. Recent attempts to modify the insect cell secretory pathway by overexpressing processing factors have demonstrated the potential to overcome these limitations.

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