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    Neuroreport. 1999 Feb 25;10(3):563-8.

    Isolation of human delta-catenin and its binding specificity with presenilin 1.

    Tanahashi H, Tabira T.

    Source

    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan.

    Abstract

    We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1.

    PMID:
    10208590
    [PubMed - indexed for MEDLINE]

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