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Bioorg Med Chem Lett. 1999 Mar 22;9(6):885-90.

Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines.

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  • 1Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA.

Abstract

We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability data of the ODNs along with their capability to induce RNase H activity are presented.

PMID:
10206555
[PubMed - indexed for MEDLINE]
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