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Usp Fiziol Nauk. 1999 Jan-Mar;30(1):29-38.

[The molecular aspects of the functional heterogeneity of the GABA receptors].

[Article in Russian]

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  • 1Medical Military Academy, St.-Petersburg.

Abstract

It is generally accepted that gamma-aminobutyric acid (GABA) is one of the main inhibitory transmitter in the mammalian brain. There are three types of GABA receptors in the vertebrata central nervous system: the GABAA, GABAB and GABAC receptors. The GABAA receptor is a GABA-gated Cl- channel and is the tetramer ore the pentamer made of some classes of subunit (alpha, beta, gamma, delta). GABAB receptors are not affiliated with Cl(-) ionophore. GABAB receptors appear to be coupled to Ca2+ and K+ channels of presynaptic membranes. It seems they regulate the release of neurotransmitters release. The structural and functional properties of GABA receptors are discussed.

PMID:
10205817
[PubMed - indexed for MEDLINE]
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