Science. 1999 Apr 16;284(5413):502-4.

Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors.

Freedman MS, Lucas RJ, Soni B, von Schantz M, Muñoz M, David-Gray Z, Foster R.

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Department of Biology, Alexander Fleming Building, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK.

Abstract

Circadian rhythms of mammals are entrained by light to follow the daily solar cycle (photoentrainment). To determine whether retinal rods and cones are required for this response, the effects of light on the regulation of circadian wheel-running behavior were examined in mice lacking these photoreceptors. Mice without cones (cl) or without both rods and cones (rdta/cl) showed unattenuated phase-shifting responses to light. Removal of the eyes abolishes this behavior. Thus, neither rods nor cones are required for photoentrainment, and the murine eye contains additional photoreceptors that regulate the circadian clock.

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Science. 1999 Apr 16;284(5413):421-2.

PMID:: 10205061; [PubMed - indexed for MEDLINE]

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