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1: Bioorg Med Chem Lett. 1999 Mar 8;9(5):737-42.Click here to read Links

Studies towards the identification of potent, selective and bioavailable thrombin inhibitors.

Ambler J, Baker E, Bentley D, Brown L, Butler K, Butler P, Farr D, Dunnet K, Le Grand D, Hayler J, Janus D, Jones D, Menear K, Mercer M, Smith G, Talbot M, Tweed M.

Novartis Horsham Research Center, West Sussex.

The application of selection criteria, based on potency and physicochemical parameters, to a candidate library of thrombin inhibitors is described. The utility of the approach is exemplified by the discovery of a potent, selective and bioavailable thrombin inhibitor 62.

PMID: 10201839 [PubMed - indexed for MEDLINE]