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Trends Cell Biol. 1999 Mar;9(3):102-7.

Signal transduction by a protease cascade.

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  • 1Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.


The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

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