Pharmacol Biochem Behav. 1978 Sep;9(3):347-52.

Effects of passive immunization against morphine on heroin self-administration.

Killian A, Bonese K, Rothberg RM, Wainer BH, Schuster CR.

Abstract

Antimorphine antibodies produced in Rhesus monkeys immunized with morphine-6-hemisuccinate-BSA were passively administered to recipient monkeys trained to self-administer heroin and cocaine. Following antibody administration, changes in heroin self-administration behavior were observed which were similar to those achieved with low doses of naloxone. Both manipulations increased heroin self-administration without affecting cocaine responding.

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Effects of passive immunization against morphine on heroin self-administration.
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Effects of passive immunization against morphine on heroin self-administration.

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