Translocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis

C Herens; J P Hermanne; F Tassin; M F Fassotte; A Thiry; M Jamar; N Schaaf-Lafontaine; G Fillet; L Koulischer

doi:10.1016/s0165-4608(98)00186-1

Translocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis

Cancer Genet Cytogenet. 1999 Apr;110(1):62-4. doi: 10.1016/s0165-4608(98)00186-1.

Authors

C Herens¹, J P Hermanne, F Tassin, M F Fassotte, A Thiry, M Jamar, N Schaaf-Lafontaine, G Fillet, L Koulischer

Affiliation

¹ Department of Human Genetics, University of Liège, Belgium.

PMID: 10198625
DOI: 10.1016/s0165-4608(98)00186-1

Abstract

Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom translocation involves a pluripotent stem cell and is associated with a poor prognosis.

Publication types

Case Reports

MeSH terms

Aged
Chromosomes, Human, Pair 2*
Chromosomes, Human, Pair 3*
Humans
Male
Primary Myelofibrosis / genetics*
Translocation, Genetic*