Biochem Biophys Res Commun. 1999 Apr 13;257(2):400-4.

Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.

Yamamoto K, Shibata F, Miura O, Kamiyama R, Hirosawa S, Miyasaka N.

Source

First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan. kohyamamoto.med1@med.tmd.ac.jp

Abstract

IL-12 is a heterodimeric cytokine, composed of p40 and p35 subunits, that exerts its biological effects by binding to specific cell surface receptors. Two human IL-12 receptor proteins, designated IL-12R beta 1 and IL-12R beta 2, have been previously identified. IL-12R beta 2 has box 1 motif, box 2 motif, and three tyrosine residues in its cytoplasmic domain. In response to IL-12, Jak2 and Tyk2, family members of Janus family protein tyrosine kinases, are phosphorylated in PHA-activated T lymphocytes. The present study demonstrates that Jak2 binds to the cytoplasmic membrane-proximal region of IL-12R beta 2, and box 2 motif and tyrosine residues in the cytoplasmic domain were not required for binding. The amino-terminus of Jak2 is necessary for association with IL-12R beta 2.

PMID:: 10198225; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction. [Eur J Immunol. 1995]
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction.
Cornelis S, Fache I, Van der Heyden J, Guisez Y, Tavernier J, Devos R, Fiers W, Plaetinck G. Eur J Immunol. 1995 Jul; 25(7):1857-64.
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. [Proc Natl Acad Sci U S A. 1996]
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14002-7.
The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells. [J Biol Chem. 1997]
The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells.
Sakai I, Kraft AS. J Biol Chem. 1997 May 9; 272(19):12350-8.
Review Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor. [Ann N Y Acad Sci. 1999]
Review Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor.
Okuda K, Foster R, Griffin JD. Ann N Y Acad Sci. 1999 Apr 30; 872:305-12; discussion 312-3.
Review [Structure and function of IL-5 receptor]. [Yakugaku Zasshi. 1995]
Review [Structure and function of IL-5 receptor].
Takatsu K. Yakugaku Zasshi. 1995 Aug; 115(8):570-83.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Cytokine control of inflammation and repair in the pathology of multiple sclerosis. [Yale J Biol Med. 2012]
Review Cytokine control of inflammation and repair in the pathology of multiple sclerosis.
Rodgers JM, Miller SD. Yale J Biol Med. 2012 Dec; 85(4):447-68. Epub 2012 Dec 13.
Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells. [Immunol Cell Biol. 2011]
Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells.
Finley SD, Gupta D, Cheng N, Klinke DJ 2nd. Immunol Cell Biol. 2011 Jan; 89(1):100-10. Epub 2010 May 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyr...
Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.
Biochem Biophys Res Commun. 1999 Apr 13 ;257(2):400-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information