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    Neurology. 1978 Nov;28(11):1179-82.

    Gamma hydroxybutyrate in the monkey. IV. Dopaminergic mechanisms.

    Snead OC 3rd.

    Abstract

    The electrical seizure activity and trancelike state induced in the rhesus monkey by gamma-hydroxybutyrate (GHB) were abolished by dextroamphetamine. Dextroamphetamine blockade of this neurophysiologic effect was overcome with chlorpromazine, a dopamine receptor blocker. These results suggest that the electroencephalographic (EEG) and behavioral effects of GHB are related to effects on dopaminergic systems. Such a relationship, if substantiated by further studies, might indicate that anticonvulsant drugs used to treat petit mal epilepsy have a dopaminergic mode of action.

    PMID:
    101898
    [PubMed - indexed for MEDLINE]

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