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    Gen Pharmacol. 1999 Feb;32(2):239-44.

    Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.

    Cassano G, Susca F, Lippe C, Guanti G.

    Dipartimento di Fisiologia Generale ed Ambientale, Università di Bari, Italy. cassano@biologia.uniba.it

    The elevation of intracellular [Ca2+] induced by bradykinin (Bk) was monitored with fura-2 fluorescence in human skin fibroblasts. Neither [des-Arg10][Leu9]kallidin nor D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin (HOE140) inhibited the Ca2+ response stimulated by Bk. Moreover, each behaved as a partial agonist causing the elevation of intracellular [Ca2+].

    PMID: 10188626 [PubMed - indexed for MEDLINE]

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