Echocardiographic evaluation of adriamycin cardiotoxicity in children

Cancer Treat Rep. 1976 Sep;60(9):1281-4.

Abstract

Thirty children with malignant solid tumors receiving adriamycin had serial evaluation of left ventricular (LV) function by echocardiography. The echocardiographic studies showed a progressive decrease in myocardial contractility as evidenced by changes in several parameters of LV function with increasing cumulative doses of the drug. Using the patients as their own controls, serial echocardiography appears to be a reliable method for detecting early alteration of cardiac function in the asymptomatic patient. This technique may prove useful to prevent cardiomyopathy secondary to adriamycin and to prolong therapy beyond the currently established limits.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Child
  • Doxorubicin / adverse effects*
  • Doxorubicin / therapeutic use
  • Echocardiography*
  • Heart / drug effects*
  • Heart / physiopathology
  • Humans
  • Infant
  • Myocardial Contraction / drug effects
  • Neoplasms / drug therapy
  • Neoplasms / physiopathology

Substances

  • Doxorubicin